Atlanta Falcons (4-3) at Indianapolis Colts (0-8)
ATLANTA minus 8
The Colts are 6-0 against the Falcons at home. Seems Atlanta is long overdue a breakthrough in this series.
The pick FALCONS
New York Jets (4-3) at Buffalo Bills (5-2)
NEW YORK plus 2
Seems like the Bills face a must-win every week, but a win in this crucial AFC East matchup could go a long way to fulfilling their playoff dreams.
The pick BILLS
Seattle Seahawks (2-5) at Dallas Cowboys (3-4)
SEATTLE plus 12
The Cowboys were dismantled and embarrassed by the Eagles last week on the road. They get to take it out on the woeful Seahawks at home.
The pick COWBOYS
Miami Dolphins (0-7) at Kansas City Chiefs (4-3)
MIAMI plus 5
The Dolphins haven't won a game since Dec. 12, 2010. With Matt Moore at quarterback, why start now?
The pick CHIEFS
Cleveland Browns (3-4) at Houston Texans (5-3)
CLEVELAND plus 11
The surprisingly stout Cleveland pass defence (No. 2 in NFL) will mean another big day for Houston running back Arian Foster.
The pick TEXANS
Tampa Bay Buccaneers (4-3) at New Orleans Saints (5-3)
TAMPA BAY plus 9
Tampa always plays tough at the Superdome (5-1 since 2001), and needs this game to stay in close NFC South race.
The pick BUCCANEERS
San Francisco 49ers (6-1) at Washington Redskins (3-4)
SAN FRANCISCO minus 4
A middle-of-the-road Bills defence held the Redskins to 26 yards rushing last week in Toronto. The top-ranked 49ers could shut them out.
The pick 49ERS
Denver Broncos (2-5) at Oakland Raiders (4-3)
DENVER plus 9
Thus ends Denver's Tim Tebow experiment? On the other side, after two weeks of learning the playbook, the Raiders' Carson Palmer experiment truly begins.
The pick RAIDERS
St. Louis Rams (1-6) at Arizona Cardinals (1-6)
ST. LOUIS minus 3
It could be a battle of the backups, as Rams QB Sam Bradford (ankle) and Cards QB Kevin Kolb (toe) might sit this one out.
The pick CARDINALS
Cincinnati Bengals (5-2) at Tennessee Titans (4-3)
CINCINNATI plus 3
With Chris Johnson seemingly still slowed by the bags of money he received in the off-season, the Titans' hopes will once again rest on the 36-year-old arm of Matt Hasselbeck.
The pick TITANS
New York Giants (5-2) at New England Patriots (5-2)
NEW YORK plus 9
Hmm, the Giants have been made the underdogs against the Patriots. Haven't we seen that somewhere before?
The pick GIANTS
Green Bay Packers (7-0) at San Diego Chargers (4-3)
GREEN BAY minus 6
With a touchdown-to-interception ratio of 7 to 11 this season, things don't look good for Phillip Rivers and the Chargers against Green Bay's ball-hawking secondary.
The pick PACKERS
Baltimore Ravens (5-2) at Pittsburgh Steelers (6-2)
BALTIMORE plus 4
Game-time temperature will hover around zero in the first matchup between the two rivals since Baltimore's season-opening 35-7 rout. But then revenge is a dish best served cold.
The pick STEELERS
Chicago Bears (4-3) at Philadelphia Eagles (3-4)
CHICAGO plus 8
The Bears, having given up an average of 5.2 yards a rush this season, head to Philadelphia to take on Michael Vick and LeSean McCoy, who have combined for 414 yards on the ground their past two games. Ouch.
The pick EAGLES
Bye Week: Detroit, Minnesota, Carolina, Jacksonville
Last week: 5-7-1