Tyler Ennis scored in regulation time and added the shootout winner to give the Buffalo Sabres a 4-3 victory over the Ottawa Senators on Saturday night.
Nathan Gerbe and Marcus Foligno also scored for the Sabres (32-29-8). Ryan Miller stopped 33 shots.
Erik Karlsson scored twice and Erik Condra also scored for the Senators (36-26-8), while Ben Bishop made 38 saves.
The Senators played the final 67 seconds of overtime shorthanded after Karlsson took a tripping penalty. Bishop made two great saves to force the game to a shootout.
Karlsson gave the Senators a 3-2 lead at the seven-minute mark of the third as he took advantage of a turnover just inside the blue-line and fired a wristshot past Miller to make it 3-2.
Marcus Foligno tied the game 3-3 with his first NHL goal as his backhander deflected off a stick and past Bishop.
The Senators threw 21 shots at Miller in the second, but after 40 minutes the game was tied 2-2.
The Sabres tied it 1-1 as Gerbe was able to take advantage of a screened Bishop. Ottawa then regained the lead midway through the period on Karlsson's 17th of the season. Miller attempted to stop Karlsson's sharp angle shot, but instead the puck bounced off his shoulder and into the net.
Karlsson's performance was even more impressive, considering he had been a game-time decision.
With 18.6 seconds remaining in the first period, Ennis tied the game as he grabbed a rebound and raised it over a sprawled Bishop.
The Senators took a 1-0 lead on Condra's short-handed goal, his first in 30 games. Condra took advantage of a turnover at the Senators blue-line and broke in alone on Miller and beat him with a quick wristshot.
This was the sixth and final meeting between the two teams with the the season series 3-3.
Notes: The Senators were without G Craig Anderson (finger, indefinitely), C Peter Regin (shoulder, out for season), C Jesse Winchester (concussion, indefinitely). D Matt Carkner, RW Bobby Butler and C Zenon Konopka were a healthy scratch. The Sabres were without D Andrej Sekera (flu, day-to-day), C Jochen Hecht (concussion, out indefinitely), LW Thomas Vanek (upper body, day-to-day). C Cody McCormick was a healthy scratch.