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Manchester City's Nicolas Otamendi and Fernandinho react after Sergio Aguero misses a chance to score during the club’s 4-3 loss to Liverpool Sunday.PHIL NOBLE/Reuters

Manchester City's 22-match unbeaten run in the Premier League came to a crashing halt with a 4-3 loss to Liverpool in a wild and thrilling game at Anfield on Sunday.

City finally stumbled at a ground where the team has a long history of struggles — with just one league win in 37 years — and was ultimately undone by nine minutes of madness around the hour mark when Liverpool scored three goals.

With the score at 1-1, Roberto Firmino deftly chipped goalkeeper Ederson Moraes to regain the lead for Liverpool in the 59th minute. Sadio Mane smashed a rising shot high into the net in the 61st and Mohamed Salah capitalized on a weak clearance from Ederson to score from 45 metres (yards) in the 68th.

All three goals featured errors by what was previously the tightest defence in the league, as City failed to handle Liverpool's high press led by the irrepressible Firmino.

City threatened an amazing comeback after goals by Bernardo Silva, in the 84th, and Ilkay Gundogan, in the first minute of stoppage time, but Liverpool held on in a nervy finale.

Before Sunday, City had won 20 games and drawn its other two this season, leading many to believe Pep Guardiola's side could emulate Arsenal's "Invincibles" of the 2003-04 season.

Liverpool away always looked like being the toughest of City's remaining 16 games and so it proved, with Alex Oxlade-Chamberlain putting the hosts in front in the ninth minute. Leroy Sane equalized just before halftime.

A triumph in 2003 was City's only win at Anfield since 1981, and Guardiola's team started as if it knew the recent history of the fixture.

Liverpool hounded and harassed City, with ex-Red Raheem Sterling in particular a target of Liverpool's players and crowd. Firmino led the press from his position as central striker and it was the Brazilian's hard work off the ball that created Liverpool's goal.

Firmino dispossessed Fernandinho, allowing Oxlade-Chamberlain to take up the loose ball, run forward and send in an angled drive that flew low past goalkeeper Ederson.

Sterling was jeered relentlessly and even forced off the pitch at one point by marker Andrew Robertson. Later, he squared up to Robertson after a late clip of his heels and was then booked for a late challenge on Georginio Wijnaldum.

Sane's equalizer came against the run of play and was avoidable, as far as Liverpool was concerned. Joe Gomez misjudged Kyle Walker's long ball and Sane got in behind him, before jinking into the area and firing in a shot that beat Loris Karius at his near post.

Liverpool didn't deserve to be out of the lead and stormed back in a madcap nine-minute spell around the hour mark when City's defence was ripped apart.

Firmino barged aside John Stones and chipped Ederson to make it 2-1 in the 59th. Moments later, Mane curled a shot against the post but was more precise the following minute when he lashed home a left-footed piledriver from the edge of the area after Nicolas Otamendi was dispossessed.

Then Salah delivered the punishment for City, pouncing on Ederson's weak clearance and returning a 45-meter shot over the goalkeeper and into an empty net.

Guardiola tried to encourage his players from the sidelines as Liverpool's whole team celebrated inside a raucous Anfield, and City almost recovered.

Silva buried a low shot after a mazy run from Gundogan, who then poked in from eight meters for 4-3. There was to be no equalizer this time, though.

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